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Buy Demerol (Meperidine HCL) 100mg pills is for moderate to severe Migraine pain management. Migraineurs find Demerol is a useful therapy when taken with a small amount of food and then laying down in a dark and quite room. It also works well when taken with an anti-nausea medication.

ER’s commonly use the injectable version of this drug with prochlorperazine (Compazine) to treat run away severe Migraine. Because it is very strong narcotic, it should be used when abortive medications fail (also know as a rescue medication in Migraine circles) or when abortives are not appropriate (such as with Basilar or Hemiplegic Migraine).

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Meperidine hydrochloride (also known as pethidine outside the US) is a synthetic opiate agonist belonging to the phenylpiperidine class. Other members of this group include alfentanil, diphenoxylate, fentanyl, loperamide, and sufentanil. The chemical structure of meperidine is similar to local anesthetics. Meperidine is recommended for relief of moderate to severe acute pain and has the unique ability to interrupt postoperative shivering and shaking chills induced by amphotericin B.

Meperidine has also been used for intravenous regional anesthesia, peripheral nerve blocks and intraarticular, epidural and spinal analgesia. A high incidence of side effects limits the utility of meperidine in these situations. According to the Agency for Health Care Policy and Research Clinical Practice Guideline for acute pain management in operative or medical procedures and trauma, meperidine is recommended only for use in very brief courses in patients who are healthy and/or have problems with other opiate agonists. Meperidine is considered a second-line agent for the treatment of acute pain. Meperidine is commonly underprescribed in terms of dose and interval.

Meperidine is metabolized to normeperidine, a compound capable of inducing seizures at high concentrations. Meperidine is not recommended for the treatment of chronic pain because of the risk of seizures with repetitive dosing and its short duration of action. Meperidine is often used as a rescue medication for treatment of Migraine, meaning used for controlling severe Migraine when a Migraineur dose not respond to abortive treatments or the Migraineur cannot use effective abortive regimes when they are contraindicated. Meperidine is available in both oral and parenteral forms and was approved by the FDA and marketed in 1942.

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Meperidine is primarily a kappa-opiate receptor agonist and also has local anesthetic effects. Meperidine has more affinity for the kappa-receptor than morphine. Opiate receptors include µ (mu), kappa (kappa), and delta (delta), which have been reclassified by an International Union of Pharmacology subcommittee as OP1 (delta), OP2 (kappa), and OP3 (µ).Buy Demerol (Meperidine HCL) 100mg pills

These receptors are coupled with G-protein (guanine-nucleotide-binding protein) receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Opioid-G-protein systems include adenylyl cyclase-cyclic adenosine monophosphate (cAMP) and phospholipase3 C (PLC)-inositol 1,4,5 triphosphate (Ins(1,4,5)P3)-Ca).

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